Pediatric literature shift: Growth of meta-analyses was 23 times greater than growth of randomized trials
نویسندگان
چکیده
منابع مشابه
Meta-analyses of randomized controlled trials.
A new type of research, termed meta-analysis, attempts to analyze and combine the results of previous reports. We found 86 meta-analyses of reports of randomized controlled trials in the English-language literature. We evaluated the quality of these meta-analyses, using a scoring method that considered 23 items in six major areas--study design, combinability, control of bias, statistical analys...
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BACKGROUND An important step toward improvement of the conduct of pediatric clinical research is the standardization of the ages of children to be included in pediatric trials and the optimal age-subgroups to be analyzed. METHODS We set out to evaluate empirically the age ranges of children, and age-subgroup analyses thereof, reported in recent pediatric randomized clinical trials (RCTs) and ...
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P a t i e n t s 343 children who were 4 to 11 years of age (mean age 8 y, 72% boys); had a sexual maturity rating of Tanner stage 1; required treatment with fluticasone propionate, 100 to 200 μg/d, or beclomethasone dipropionate or budesonide, 200 to 500 μg/d, for ≥ 8 weeks before study entry at a constant dosage for ≥ 4 weeks before the run-in period; had a mean morning peak expiratory rate (P...
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مطالعات قبلی بازار بیمه را به صورت کلی در نظر می گرفتند اما در این مطالعه صنعت بیمه به عنوان متغیر مستفل به بیمه های زندگی و غیر زندگی شکسته شده و هم چنین بیمه های زندگی به رشته های مختلف بیمه ای که در بازار بیمه ایران سهم قابل توجهی دارند تقسیم میشود. با استفاده از روشهای اقتصاد سنجی داده های برای دوره های 48-89 از مراکز ملی داده جمع آوری شد سپس با تخمین مدل خود بازگشتی برداری همراه با تعدادی ...
15 صفحه اولDiscrepancies between meta-analyses and subsequent large randomized, controlled trials.
BACKGROUND Meta-analyses are now widely used to provide evidence to support clinical strategies. However, large randomized, controlled trials are considered the gold standard in evaluating the efficacy of clinical interventions. METHODS We compared the results of large randomized, controlled trials (involving 1000 patients or more) that were published in four journals (the New England Journal...
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ژورنال
عنوان ژورنال: Journal of Clinical Epidemiology
سال: 2020
ISSN: 0895-4356
DOI: 10.1016/j.jclinepi.2020.01.014